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在挪威的火生产中逐步淘汰monensin会减少Bifidobacterium spp. 在增强微生物多样性的同时,
Håkon Pedersen Kaspersen1, Eva Lena Estensmo1, Jannice Schau Slettemeås1
1Norwegian Veterinary Institute, Ås, Norway.
Microbial genomics
|August 20, 2025
概括
对火的预防性使用减少了肠道微生物群的多样性,但增加了有益的Bifidobacterium物种. 早期的抗生素治疗对火肠道健康没有长期影响.
科学领域:
- 动物科学
- 微生物学
- 动物医学
背景情况:
- 菌病和死肠炎是火生产中的重大健康问题.
- 在挪威,一种离子体菌抑制剂Monensin被用于预防,直到2022年.
- 由于死肠炎而导致抗生素使用的增加.
研究的目的:
- 调查和抗生素治疗对火白内障微生物群的影响.
- 了解蒙宁素禁用对火肠道健康的影响.
主要方法:
- 102个挪威火群样本的基因组测序.
- 使用Taxprofiler和R进行多样性和差异性丰度的生物信息分析.
- 暴露和未暴露的火间的阴微生物群的比较.
主要成果:
- 蒙宁素暴露显著降低了火阴微生物群的α和β多样性.
- 增加了Bifidobacterium spp的数量 (例如,B. pullorum,B. longum) 在使用蒙宁素时观察到.
- 蒙宁的使用减少了Megamonas和Megasphaera物种;雌性火中的Clostridium丰度更高.
结论:
- 在火中使用素会减少肠道微生物群的多样性,但会促进有益的Bifidobacterium spp.
- 氧甲素 (青素V) 治疗似乎不会导致长期的阴微生物群变化.
- 需要对减少Bifidobacterium spp的影响进行进一步的研究. 在戒药后出现多样性变化.
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