相关实验视频
Updated: Sep 10, 2025

06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.6K
儿童癌症幸存者的基底细胞癌风险预测
Cindy Im1, Christina Boull1,2, Zhe Lu3
1Department of Pediatrics, University of Minnesota, Minneapolis, USA.
Journal of the National Cancer Institute
|August 20, 2025
概括
新的模型预测了儿童癌症幸存者的基细胞癌 (BCC) 风险,其表现优于目前的指导方针. 一个在线计算器现在可以指导个性化,基于风险的长期健康查.
科学领域:
- 癌症学
- 流行病学
- 生物统计学
背景情况:
- 儿童癌症幸存者患基底细胞癌 (BCC) 的风险增加.
- 目前的查指导方针可能无法准确地对该群体的BCC风险进行分层.
- 需要开发精确的,年龄特定的风险预测模型来进行有针对性的查.
研究的目的:
- 开发和验证特定年龄的模型来预测儿童癌症幸存者的BCC风险.
- 将新型预测模型的性能与现有的查指南进行比较.
- 提供个性化查建议的工具.
主要方法:
- 在儿童癌症幸存者研究 (CCSS) 中使用了23166名五年幸存者的数据.
- 开发了统计/机器学习模型,包括XGBoost,包含详细的癌症治疗预测因素.
- 在圣朱德终身队列 (SJLIFE) 的5314名幸存者中外部验证模型,并使用AUROC和AUPRC评估性能.
主要成果:
- 在50岁时,BCC的累积发病率为CCSS的15%和SJLIFE的21%.
- XGBoost模型表现出强大的分辨率 (AUROC40y=0.75,AUROC50y=0.76) 和精度 (AUPRC40y=0.20,AUPRC50y=0.52).
- 新型模型的表现优于当前儿童瘤组 (COG) 的指导方针,重新分类显著比例的幸存者进行风险分层查.
结论:
- 对儿童癌症幸存者的验证BCC风险预测模型明显优于当前的实践指南.
- 开发的模型和相关的在线风险计算器可以支持基于证据的个性化查建议.
- 这些工具可以帮助优化儿童癌症幸存者的长期随访护理,
相关概念视频
Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Cancer Survival Analysis
453
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
453
The Retinoblastoma Gene
4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K

