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Updated: Jun 9, 2026

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
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Published on: May 19, 2018

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人类诱导的多能干细胞基于脂肪代谢相关的TM6SF2-E167K变异的肝脏建模

Lanuza A P Faccioli1,2,3, Yiyue Sun1,2,4, Olamide Animasahun5,6,7

  • 1Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Hepatology (Baltimore, Md.)
|August 20, 2025
PubMed
概括

一个新的人类细胞模型显示TM6SF2-E167K突变导致肝脏脂肪积累和ER压力. 针对蛋白质折叠可以缓解这些与代谢功能障碍相关的脂肪性肝病影响.

关键词:
TM6SF2 E167K 其他人类肝细胞其他国家脂质新陈代谢肝脏疾病模型

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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...