在以人口为基础的查计划中减少大动脉直径和下动脉动脉瘤的流行率
Antti Siika1, Anton Axelsson1, Nina Fattahi1,2
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
The British journal of surgery
|August 20, 2025
概括
在65岁的男性中,腹腔大动脉瘤 (AAA) 的患病率下降,但较小的大动脉增加了死亡风险. 戒烟显著降低了AAA的进展和死亡率.
科学领域:
- 血管外科手术
- 流行病学
- 公共卫生
背景情况:
- 在以人口为基础的腹腔大动脉瘤 (AAA) 查计划中,研究了下大动脉直径的时间趋势及其与死亡率的联系.
- 分析了14年的AAA个体风险因素分布和结果的变化.
研究的目的:
- 在查计划中探索大动脉直径的时间趋势及其与长期死亡率的关联.
- 分析随着时间的推移,AAA患者的风险因素和结果的变化.
主要方法:
- 2010-2023年以人口为基础的队列研究,包括152,000名65岁的男性被邀请参加AAA查.
- 从区域查数据库中提取大动脉直径和死亡率数据.
主要成果:
- 对117,120名男性进行了检查,观察到大动脉平均直径减少和AAA患病率.
- 发现主动脉初始直径与死亡率之间存在非线性关联;随着主动脉大小的增加,5年死亡率.
- 戒烟与手术延迟和5年死亡率降低有关 (目前吸烟者的比例为5. 6%和11. 1%).
结论:
- 亚动脉和亚动脉的患病率有所下降,而小动脉的患病率略有增加.
- 与直径正常的男性相比,患有小动脉动脉或动脉瘤的男性在5年内死亡的风险高1.5至2.5倍.
- 戒烟会阻止AAA的进展,并与死亡率的降低有关.
相关概念视频
Aneurysm III: Interprofessional Care
24
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
24
Aneurysm II: Clinical Manifestations and Diagnostic Studies
22
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
22
Aneurysm I: Introduction
25
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
25
Aortic Regurgitation III: Medical Management
42
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
42
Aortic Regurgitation I: Introduction
36
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
36
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
38
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
38


