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Updated: May 9, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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化C20-epi-deoxysalinomycin衍生物:抗癌活性的合成和评估

Jing Zhang1, Min Sun2, Zhigang Yang2

  • 1School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, China.

Chemistry & biodiversity
|August 20, 2025
PubMed
概括

化增强了沙利诺米的抗癌能力. 一种新的衍生物5f显示出作为潜在的抗瘤剂的强度和选择性,证明了化沙利诺的治疗价值.

关键词:
抗瘤剂 细胞毒性分析

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Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...