在微乳液系统中对口服殖民生物膜的抗菌作用
C F B Bastos1, F N Gomes-Filho1, M H S Borges-Grisi1
1Universidade Federal da Paraíba - UFPB, João Pessoa, PB, Brasil.
Brazilian journal of biology = Revista brasleira de biologia
|August 20, 2025
概括
肉甲基微乳液对像Streptococcus mutans这样的口腔细菌有不同的抗菌作用. 与素相比,素增强配方 (CEQ) 的抗菌活性有限.
科学领域:
- 口腔微生物学
- 在牙科中使用纳米技术
- 抗微生物剂
背景情况:
- 突变性肠杆菌是导致牙腐烂的主要原因.
- 开始性口腔细菌包括Streptococcus mitis和Streptococcus oralis.
- 用抗菌药物破坏生物膜有助于预防.
研究的目的:
- 评估含甲酸的微乳液 (CE和CEQ) 对S. mutans,S. mitis和S. oralis的抗菌功效.
- 将CE和CEQ微乳液与素的活性进行比较.
- 研究基托桑对微乳液抗菌性能的影响.
主要方法:
- 用甲制备的微乳液 (CE) 和用素增强的版本 (CEQ).
- 在24小时和48小时内化单种口腔生物膜 (S. mutans,S. mitis,S. oralis).
- 生物膜暴露于CE和CEQ微乳液,然后进行MTT测定以分析代谢活动.
主要成果:
- 在经过测试的生物膜中,甲微乳液的活性是可变的,不取决于度.
- 对于大多数疾病,CE和CEQ系统的抗菌活性低于0. 12%的素.
- 基托桑基系统 (CEQ) 的总体抗菌活性较低.
结论:
- 肉甲基微乳液对口服生物膜具有抗菌作用,但疗效因微生物而异.
- 添加基托桑并没有显著增强甲基微乳液的抗菌活性.
- 需要进一步研究以优化有效预防牙损伤的配方.
相关概念视频
Antimicrobial Effectiveness
156
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
156
Biofilms
271
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
271


