基于学校和初级保健的多组件干预措施的实施评估,以改善HPV疫苗覆盖率:PrevHPV随机对照试验的结果
Aurélie Bocquier1, Maïa Simon2, Morgane Michel3
1Université de Lorraine, Inserm, INSPIIRE, Nancy F-54000, France.
Journal of infection and public health
|August 20, 2025
概括
增加人类乳头瘤病毒 (HPV) 疫苗覆盖率需要学校和全科医生的联合干预. 在学校接种疫苗和GP培训显著提高了青少年的HPV疫苗接种率.
科学领域:
- 公共卫生
- 疫苗学
- 医疗服务研究
背景情况:
- 法国的人类乳头瘤病毒 (HPV) 疫苗覆盖率低于预期.
- 在PrevHPV计划中,开发和评估了一种多组分干预措施,以改善HPV疫苗接种.
- 这项研究评估了PrevHPV干预组件的实施结果和有效性.
研究的目的:
- 评估PrevHPV干预组件的实施结果 (忠实性,剂量,覆盖范围,可接受性,可持续性).
- 确定每个成分对HPV疫苗覆盖率的影响.
- 确定影响学校实施干预措施的因素.
主要方法:
- 一个集群随机对照试验,涉及91个法国城市.
- 使用活动报告,问卷和重点小组的混合方法.
- 使用已建立的框架评估实施结果;通过HPV VC测量有效性.
主要成果:
- 在干预组件中观察到高准确性,可接受性和可持续性.
- 学校退学和调动全科医生的挑战影响了剂量和覆盖范围.
- 在学校接种疫苗和全科医生培训显著增加了HPV病毒感染率;教育/激励成分无意义.
结论:
- 结合基于学校和初级保健的干预措施有效增加了青少年的HPV感染率.
- 这些发现为实际实施HPV疫苗策略提供了实用见解.
- 在教育和医疗环境中进行有针对性的干预对于实现公共卫生目标至关重要.
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