这页已由机器翻译。其他页面可能仍然显示为英文。 View in English

氧化的表达在瘤内毛细血管和邻近清细胞细胞癌的近接管细胞中增加

Roberto Silva ¹, Jorge Reis Almeida ², Ana Rita Coelho ³

¹University of Porto - Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal..
²i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.
³University of Porto - Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
⁴i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.; University of Porto - Instituto de Ciências Biomédicas Abel Salazar, R. de Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
⁵ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
⁶i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.; RISE - Health, University of Porto - Faculty of Medicine, Alameda Prof. HernRISE - Healthni Monteiro, 4200-319 Porto, Portugal.
⁷University of Porto - Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal.

⁰University of Porto - Faculty of Medicine, Pathology Department, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.; ULS São João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal..

Experimental and Molecular Pathology +

|

2025年八月20日

在PubMed上查看摘要

概括

过氧 (PXDN) 在清细胞细胞癌 (ccRCC) 毛细血管和邻近的组织中过度表达. 这表明PXDN可能在ccRCC中驱动瘤血管生成和恶性瘤.

科学领域

癌症学
生物化学
细胞生物学

背景情况

过氧化素 (PXDN) 是一种对基底膜完整性至关重要的血过氧化酶,通过IV型原交联.
在各种癌症中,PXDN过度表达与不良的临床结果相关,但其在细胞癌 (RCC) 中的作用在很大程度上是未知的.

研究的目的

研究不同类型的细胞癌 (RCC) 和相邻的非瘤脏组织中的PXDN表达模式.
探索PXDN在瘤血管生成中的潜在作用及其与RCC恶性瘤的关联.

主要方法

使用免疫组织化学分析PXDN表达.
从清晰细胞RCC (ccRCC),染色细胞RCC (chRCC) 和脏瘤病例中检查了瘤和相邻的非瘤组织.

主要成果

与其他瘤类型 (包括瘤) 相比,ccRCC的瘤内毛细血管显著增加PXDN表达.
与瘤细胞相比,与ccRCC相邻的非新发性表皮细胞中观察到PXDN水平的升高.

结论

在ccRCC中,PXDN可能有助于瘤血管生成,可能促进转移和恶性瘤.
PXDN可能参与瘤与邻近组织之间的通信,这一机制需要进一步研究.

关键词:

血管新生染色细胞瘤清细胞细胞癌细胞瘤过氧化

相关概念视频

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...