骨矿物质密度在5岁时在非常早产的儿童中,与按期出生的儿童相比,骨矿物质密度在5岁时
A M le Clercq1, D J Dorrepaal2, G F Hasperhoven1
1Department of Neonatal and Pediatric Intensive Care, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands.
Clinical nutrition (Edinburgh, Scotland)
|August 20, 2025
概括
非常早产 (VPB) 儿童在5岁时表现出较低的骨矿物质密度 (BMD),但在考虑体型后,这种差异消失了. 这表明改变了生长,而不是骨矿化问题,可能解释了VPB幸存者的骨密度差异.
科学领域:
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
- 骨的发育 骨的发育
背景情况:
- 非常早产 (VPB,孕期<32周) 与由于子宫外骨矿化减少而导致骨发育受损有关.
- 新生儿重症监护室 (NICU) 的营养方案旨在支持VPB婴儿的骨矿物质密度 (BMD).
研究的目的:
- 评估NICU营养方案是否足够支持VPB儿童的BMD.
- 为了比较VPB儿童和按期出生的儿童在5岁时的BMD.
主要方法:
- 前性队列研究比较了94名VPB儿童和259名按时出生的儿童.
- 双能X射线吸收计 (DXA) 在5岁时测量了全身减去头部 (TBLH) BMD.
- 使用标准偏差分数 (SDS) 和多重回归分析来比较BMD并确定相关因素.
主要成果:
- 在5岁时,VPB儿童的平均身高,体重,脂肪质量和瘦身质量SDS较低.
- 与按期出生的同龄人相比,VPB儿童的BMDTBLH显著降低,BMDTBLH的患病率更高.
- 在调整身体大小后,VPB和按期出生的孩子之间的BMDTBLH的差异不再显著.
结论:
- 在5岁时,VPB儿童的BMDTBLH较低,尽管在正常范围内.
- 在VPB儿童中,较低身高和瘦体质的SDS解释了观察到的BMD差异.
- 结果表明,改变的生长,而不是异常的骨矿化,可能是VPB幸存者的骨密度变化的基础.
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