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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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相关实验视频

Updated: Sep 10, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment &#8212; Challenges and Innovations in Cancer Prognosis
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淋巴结转移和微血管侵袭独立于肝内胆管癌的微淋巴侵袭影响预后

Chaoqun Wang1, Ying Zhu1, Haoting Sun1

  • 1Hepatobiliary Surgery Center, Department of General Surgery, Huashan Hospital,& Cancer Metastasis Institute, Fudan University, Shanghai, 200040, China.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|August 20, 2025
PubMed
概括
此摘要是机器生成的。

微淋巴侵袭 (MLI) 是肝内胆管癌 (ICC) 的一个关键的独立预后因素. 结合MLI评估可以改善超出淋巴结转移 (LNM) 和微血管入侵 (MVI) 的生存预测.

关键词:
肝脏内胆血管癌微淋巴感染预测情况

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科学领域:

  • 癌症学
  • 外科病理学
  • 癌症的预测

背景情况:

  • 肝内胆管癌 (ICC) 的预后很复杂.
  • 独立于淋巴结转移 (LNM) 和微血管侵袭 (MVI) 的微淋巴侵袭 (MLI) 的评估至关重要.

研究的目的:

  • 确定MLI在ICC患者的预后意义.
  • 评估MLI对生存结果的独立预测价值.

主要方法:

  • 对137名接受治疗切除的ICC患者进行回顾性队列研究.
  • 免疫组织化学染色 (D2-40,α-SMA,CD34,CK19) 用于MLI和MVI的评估.
  • 基于入侵状态的无复发生存率 (RFS) 和整体生存率 (OS) 的比较.

主要成果:

  • 独立于LNM,MLI与减少的OS和RFS有显著的关联.
  • MLI状态预测的生存结果与LNM相似.
  • 多变量分析发现MLI是OS和RFS的独立预后因素.

结论:

  • 在ICC中,MLI是一个关键的独立预后标志物.
  • 对ICC的预测评估应包括MLI评估.
  • 了解MLI可以更好地预测患者的结果.