在口腔皮细胞癌的诱导疗法中,循环瘤组织修饰的HPVDNA动态的预测值
Megan Tang1, Max Dougherty2, Leslie Worona2
1Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
人类乳头瘤病毒阳性口腔状细胞癌 (HPVOPC) 诱导治疗期间瘤组织修饰病毒 (TTMV) 清除的延迟预示着治疗失败. 早期的TTMV清除与更好的结果有关,这表明其在指导治疗中的有用性.
科学领域:
- 癌症学
- 病毒学
- 生物标志物发现
背景情况:
- 瘤组织修饰病毒 (TTMV) HPV DNA 是人类乳头瘤病毒阳性口腔状细胞癌 (HPVOPC) 的敏感和特定生物标志物.
- 监测TTMV动力学可以提供对治疗反应和患者结果的见解.
研究的目的:
- 在接受诱导化疗 (IC) 或诱导化疗 (ICI) 的HPVOPC患者中研究TTMVDNA水平的动力学.
- 分析TTMV清除模式对治疗结果的预测价值,包括复发和生存.
主要方法:
- 在局部发达的HPVOPC患者接受了IC或ICI,随后是辅助免疫治疗 (CRT) 或不辅助免疫治疗.
- 在治疗前,每次化疗后,CRT后和监测期间,追溯测量了TTMV DNA水平.
主要成果:
- 第一个IC周期后的TTMV快速清除与复发风险较低 (p=0. 046) 和TTMV基线水平较低 (p=0. 049) 相关联.
- 在诱导治疗期间延迟的TTMV清除强烈预测系统性衰竭.
- 在CRT后,所有患者都获得了TTMV阴性,但6/ 28患者在监测期间出现了复发.
结论:
- 在HPVOPC的诱导治疗期间延迟的TTMV清除是系统性衰竭的强烈预测因素.
- TTMV动力学可能有助于识别可能受益于更密集的全身治疗的患者.
- 在更大的群体中进行进一步验证是有必要的,以确认这些产生假设的发现.
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