产前暴露于微塑料和带血液中的雄激素和葡萄皮质激素
Bingying Liu1, Dongming Zheng1, Jia Wang2
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Ecotoxicology and environmental safety
|August 20, 2025
概括
胎盘微塑性暴露与胎儿激素水平的改变有关,可能会破坏内分泌发育. 这项研究发现特定塑料与皮质醇,雄激素及其比例的变化之间存在关联.
科学领域:
- 环境健康
- 内分泌学
- 毒理学
背景情况:
- 胎盘微塑污染对胎儿发育的担忧越来越大.
- 了解微塑料对胎儿内分泌系统的影响至关重要.
研究的目的:
- 研究胎盘微塑性负担与带激素水平之间的关联.
- 评估微塑料混合物的内分泌干扰潜力.
主要方法:
- 在1324名孕妇中使用LD-IR化学成像量化胎盘微塑料 (PVC,PP,PBS).
- 通过LC-MS/MS测量带血中的荷尔蒙 (皮质醇,皮质素,DHEA,androstenedione).
- 使用回归模型,g计算和BKMR分析个体和混合效应.
主要成果:
- 在所有胎盘中检测到微塑料 (中位数为12颗/ 10μg).
- 较高的PVC,PBS和总微塑料与较低的皮质醇和皮质相关.
- PBS,PVC和总微塑料与增加的DHEA和androstenedione有关,从而降低了荷尔蒙比率.
结论:
- 胎盘微塑性暴露与胎儿激素特征的显著变化有关.
- 有证据表明微塑料是内分泌干扰剂,影响葡萄皮质和雄激素水平.
- 这些发现突出了潜在的性别特异性影响,并需要进一步研究微塑料诱导的发育风险.
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