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Updated: Sep 10, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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非小细胞肺癌中的CDKN2A交替:使用下一代测序的评估

Xu Feng1, Heng Chang1, Yuyin Xu1

  • 1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.

Pathology, research and practice
|August 20, 2025
PubMed
概括

下一代测序 (NGS) 对肺癌中CDKN2A缺失检测具有很高的准确性,但可能会出现错误的阳性结果. 仔细解释NGS结果至关重要,尤其是在中间副本数值方面.

关键词:
在CDKN2A其他国家/地区鱼类没有NGS在 NSCLC

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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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