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Updated: Sep 10, 2025

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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基于 iPSC 的基因细胞疗法对帕金森病的临床试验中免疫反应的控制

Asuka Morizane1, Emi Yamasaki2, Takero Shindo3

  • 1Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; Center for Clinical Research and Innovation, Kobe City Medical Center General Hospital, Kobe 650-0047, Hyogo, Japan.

Cell stem cell
|August 20, 2025
PubMed
概括

在中枢神经系统 (CNS) 中使用诱导多能干细胞 (iPSC) 的帕金森病细胞疗法可能需要较少的免疫抑制. 人类白细胞抗原 (HLA) 在iPSC衍生细胞上的低表达有助于成功植入免疫特权的中枢神经系统.

关键词:
帕金森病细胞治疗临床试验接种人类白细胞抗原免疫排斥诱导多能干细胞定子发射断层扫描移植

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