骨肌肉质量指数与稳定精神分裂症住院患者的认知功能之间的关联
Dan Shuai1, Binyou Wang1, Duanfang Cai1
1Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Psychiatry investigation
|August 20, 2025
概括
尾骨肌质量以腰围为指数 (ASMIwc) 与精神分裂症住院患者的认知功能显著相关. 这一发现凸显了肌肉质量在维持这一群体认知能力方面的重要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 代谢健康 代谢健康
背景情况:
- 精神分裂症是一种慢性精神障碍,与显著的认知缺陷有关.
- 身体组成,特别是肌肉质量,越来越被认为是影响认知功能的因素.
- 在稳定的精神分裂症住院患者中,特定的尾骨肌肉质量指数与认知表现之间的关系需要进一步阐明.
研究的目的:
- 研究各种尾骨肌肉质量指数 (ASMIht,ASMIbmi,ASMIwt,ASMIwc) 与认知功能之间的相关性.
- 在稳定的精神分裂症住院患者中,使用蒙特利尔认知评估-中文版本 (MoCA-C) 评估肌肉质量指标和认知表现之间的关联.
主要方法:
- 一项涉及235名稳定精神分裂症住院患者的横截面研究.
- 收集人口统计和人体组成数据.
- 使用蒙特利尔认知评估-中文版本 (MoCA-C) 进行认知评估.
- 采用多重线性回归分析来确定肌肉质量指数和认知功能之间的关联.
主要成果:
- 对腰围指数的尾骨肌量 (ASMIwc) 与男性的MoCA-C得分有显著的关联 (r=0.323,FDR=0.004).
- 在女性中,ASMIbmi,ASMIwt和ASMIwc都与MoCA-C得分显著相关 (r=0.268-0.421,FDR <0.05).
- 与共变量调整后的回归证实ASMIwc是男性 (β=0.565,p=0.007) 和女性 (β=0.96,p=0.001) MoCA-C评分的唯一显著预测因子.
结论:
- 尾骨肌群指数为腰围 (ASMIwc) 与精神分裂症住院患者的认知功能有很大相关性.
- 这些发现表明,ASMIwc可能成为该人口认知状态的相关指标.
- 为了证实这些结果,需要在不同人群中进行进一步的验证.
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