查内镜的最佳间隔可降低胃癌死亡率:全国性队列研究
Soo-Yoon Sung1, Hyun Ho Choi2, Seung Ho Sin2
1Department of Radiation Oncology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Gastrointestinal endoscopy
|August 20, 2025
概括
每三年定期进行胃癌内镜检查,可显著降低死亡风险. 这一发现支持3年间隔作为高风险人群中GC预防的有效策略.
科学领域:
- 胃肠病学
- 癌症学
- 预防医学
背景情况:
- 胃癌 (GC) 的最佳内镜查间隔仍未确定.
- 之前的研究尚未确定最有效的GC查频率.
- 了解查的影响对于公共卫生战略至关重要.
研究的目的:
- 根据诊断前内镜查间隔,对胃癌患者的生存结果进行比较.
- 确定胃癌的最佳内镜查频率.
- 评估查间隔对胃癌死亡率的影响.
主要方法:
- 使用了韩国国家保险索赔数据,用于2010年诊断出GC的患者.
- 通过查内镜间隔对患者进行分类: ≤1, ≤2, ≤3, ≤4, ≤5, >5年,并且从未进行查.
- 在≤3年和>3年查组之间的结果比较,包括倾向性得分匹配.
主要成果:
- 总共分析了26,199名GC患者.
- 与从未进行查的人相比,查间隔≤5年显示查特异性死亡率 (HRs) 显著降低.
- 在≤3年的查组中,GC特异性死亡率的HR显著较低 (HR为0.72),而在匹配后仍然存在 (aHR为0.71).
结论:
- 在≤3年间对胃癌患者进行查,可显著降低GC特异性死亡率.
- 3年内镜检查间隔似乎是一个有效的策略,特别是在高风险地区.
- 这项研究提供了支持更短,定期查胃癌的证据.
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