在高风险成年人中使用多重PCR胃肠道面板测试进行腹生物的比较流行病学:多中心观察性研究
Jeffrey Shu1, Hannah Wang2, Anisha Misra2
1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, OH, USA.
概括
胃肠道面板 (GIP) 通常无法检测高风险患者的病原体. 当发现病原体时,肠道病原性大肠杆菌 (EPEC) 和诺罗病毒是最常见的,根据并发症情况的不同概况.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 传染性腹在免疫受损和高风险人群中存在重大风险.
- 了解这些群体中分子胃肠道面板 (GIP) 的病原体分布和诊断实用性至关重要.
研究的目的:
- 描述腹病原体在十种高风险疾病中的分布.
- 评估这些人群中GIP的诊断产量.
- 为高风险患者开发改进的诊断算法提供信息.
主要方法:
- 在12家美国医院 (2019-2024) 中,对使用BioFire FilmArray GIP测试的成年人进行了回顾性观察研究.
- 分析总体的病原体检测率,按风险状况和10个高风险状况 (ICD-10代码).
- 多变量后勤回归用于估计高风险条件对生物体检测的独立影响.
主要成果:
- 在16,570名患者中,22%的人检测到病原体;EPEC (6.4%) 和诺罗病毒 (6.1%) 是最常见的.
- 与低风险患者 (27%) 相比,高风险患者的病原体检测率较低 (19%).
- 艾滋病毒患者的细菌/寄生虫检测率更高;移植受体的病毒检测率更高.
结论:
- 大多数高风险患者的GIP测试没有产生病原体.
- 当检测到病原体时,EPEC和诺罗病毒是最常见的,根据共发病性有不同的概况.
- 结果支持风险分层测试,并突出GIP的局限性,包括潜在的错误阳性.
相关概念视频
01:23Investigation of Disease Outbreaks
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...