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主要皮肤黑色素瘤微生物组与整体生存和复发有关

Alfred A Chan¹, Juliana Noguti¹, Natalia Maverakis Ramirez²

¹The Lundquist Institute at Harbor -UCLA Medical Center, Torrance, CA 90509, USA.

The Journal of investigative dermatology

|August 20, 2025

概括

皮肤癌是黑色素瘤.

科学领域:

在瘤学瘤学.
微生物学微生物学
基因组学就是基因组学.

背景情况:

黑色素瘤是最致命的皮肤癌.
内微生物组与黑色素瘤患者的结局之间的联系在很大程度上仍未被描述.
在其他癌症中,微生物与临床结果的关联已经确立.

研究的目的:

调查原发性黑色素瘤内微生物组与临床结果之间的关联.
确定与皮肤黑色素瘤总体存活率和复发相关的特定微生物特征.

主要方法:

16S V1-V3 rRNA基因测序用于原发性黑色素瘤FFPE标本的微生物分析.
贝塔多样性分析评估了细菌组成与生存和复发的关联.
阿尔法多样性分析评估了物种丰富和临床结果之间的关系.

主要成果:

皮肤黑色素瘤的细菌组成 (β-多样性) 与整体存活率和复发率相关 (P=0.024,P=0.025).
较高的物种丰富度 (α-多样性) 与更糟糕的生存率 (P=0.048) 和更早的复发 (P=0.016) 有关.
特定的细菌,如Cutibacterium granulosum与更好的结果有关,而Leuconostoc inhae和Streptococcus salivarius与更糟糕的结果有关.

结论:

在皮肤黑色素瘤中,内微生物组的组成与患者的生存和复发有关.
特定的细菌物种可以作为黑色素瘤的预后生物标志物.
进一步研究微生物在黑色素瘤病理生理学中的作用是有必要的.

关键词:

黑色素瘤是一种黑色素瘤.微生物组是一个微生物组.总体存活率总体存活率复发性复发性复发性

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