结合凝血和炎症生物标志物在败血症分层的诊断效用:一项回顾性研究
Zhenzhen Ding1, Qian Li2, Chunyan Ma1
1Department of Laboratory Medicine and Key Laboratory of Tumor Marker Detection, Kaifeng Central Hospital, Kaifeng 475000 Henan Province, China.
概括
与淋巴细胞-C反应蛋白比率 (LCR) 和D-二次体 (DD) 的结合改善了败血症严重程度的分层. 这种组合可以提高诊断准确度,以确定病变的进展.
科学领域:
- 生物医学诊断
- 临床病理
- 败血症研究
背景情况:
- 败血症严重程度分层对于患者的治疗至关重要.
- 凝血参数和炎症标志物是败血症的潜在生物标志物.
- 需要准确的诊断工具来识别致败血症的进展.
研究的目的:
- 评估凝血参数 (PT,APTT,FIB,D-D,PTA,INR) 和炎症标志物 (PCT,CRP,IL-6,SII,LCR) 对于败血症严重程度分层的诊断效用.
- 评估所选标志物的综合诊断价值,以识别败血性休克.
主要方法:
- 对123名败血症患者和50名健康对照者的回顾性研究.
- 对凝血参数 (PT,APTT,D-D,PTA,INR) 和炎症标志物的分析 (CRP,LCR).
- 接收器操作特征 (ROC) 曲线分析以确定灵敏度,特异性和曲线下的面积 (AUC).
主要成果:
- 在败血症和对照组之间 PT,APTT,D-D,PTA,INR 和 CRP 的显著差异.
- 对PT,LCR和DD的联合检测结果为AUC为0. 8705,具有74. 5%的敏感性和68. 8%的细分性.
- 个体标志物显示出中等的诊断效用,PT对感染性休克具有最高的特异性 (82. 9%).
结论:
- 联合检测PT,LCR和DD显著提高了败血症严重程度分层的诊断准确性.
- 这种组合有助于识别进展为败血症的患者.
- 凝血和炎症标志物提供了关于败血症进展的有价值的见解.
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