心脏移植后使用糖共传输体2抑制剂:目前的知识和潜在的应用
Lisa M Raven1, Lina Brinker2, Konstantinos Sideris2
1Department of Diabetes and Endocrinology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia; School of Clinical Medicine, St Vincent's Campus, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
概括
糖共传输体2抑制剂 (SGLT2i) 对心脏移植 (HTx) 接受者来说是有前途的. 这些药物可以改善心血管,脏和代谢健康,解决移植后的关键长期并发症.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 心脏移植 (HTx) 改善了末期心力衰竭的存活率,但长期结果受到伴随性疾病的限制.
- 心血管,脏和代谢疾病等并发症在HTx后具有重大风险.
- 移植接受者经常被排除在临床试验之外,从而限制了有益治疗方法的证据.
研究的目的:
- 在心脏移植接受者中审查-葡萄糖共运输体2抑制剂 (SGLT2i) 的潜在益处.
- 探索通过SGLT2i可减轻HTx后发病率的机制性途径.
- 总结现有的实验和回顾性数据,强调前性试验的必要性.
主要方法:
- 在HTx接受者中使用SGLT2i的机制论证的审查.
- 关于SGLT2i在逆转氨酸抑制剂诱导损伤方面的实验研究摘要.
- 对评估HTx患者SGLT2i影响的回顾性研究的分析.
主要成果:
- SGLT2i具有保护性,血糖性,血管性,抗炎性和红细胞形成性作用.
- 实验研究表明,SGLT2i可以逆转与氨酸抑制剂相关的脏和胰腺损伤.
- 回顾性研究表明,SGLT2i可以改善HTx受体的血糖,体重和功能.
结论:
- SGLT2i为心脏移植受体的长期并发症管理提供了潜在的好处.
- 进一步的前性临床试验至关重要,以确认SGLT2i在这个人群中的疗效和安全性.
- 正在进行的注册试验对于推进对HTx幸存者的基于证据的护理至关重要.
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