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Updated: Sep 10, 2025

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

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亨廷丁N17区域的翻译后修饰:对自我结合和膜结合的影响

Mariana Gallo1, Raffaele Ingenito1, Marco Finotto1

  • 1IRBM S.p.A., Pomezia, Italy.

Biochimica et biophysica acta. Molecular basis of disease
|August 20, 2025
PubMed
概括

亨廷丁蛋白 (HTT) 的N17区域的翻译后修饰 (PTM) 影响其自我结合和膜结合. 增强N17螺旋性增加HTT外因子1聚合,提供了对亨廷顿病的见解.

关键词:
聚合是一种聚合.亨廷丁蛋白质外形1外形1亨廷顿病就是亨廷顿病.膜相互作用 膜相互作用N17碎片的碎片 N17碎片的碎片后翻译修改后的修改.自我关联是一种自我关联.

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