急性胰腺炎患者的正常脂肪与脂肪限制饮食:一项随机对照研究 (NouRish-AP研究)
Nutchakorn Kittisuphat1, Narisorn Lakananurak2, Pradermchai Kongkam3
1Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
概括
在急性胰腺炎 (AP) 患者中,正常脂肪饮食 (NFD) 与低脂肪饮食 (LFD) 相比,导致更好的能量摄入和生活质量 (QoL). 对于非高甘油三血症AP来说,NFD是一种安全和可行的选择.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床营养学 临床营养学
背景情况:
- 国际指导方针建议急性胰腺炎 (AP) 患者的低脂肪饮食 (LFD).
- 由于对食感性,减少能量摄入量和生活质量 (QoL) 的担忧,人们对LFD的必要性进行了讨论.
- 在AP中,没有随机对照试验直接将LFD与正常脂肪饮食 (NFD) 进行比较.
研究的目的:
- 评估NFD与LFD在轻度至中度重度非高甘油血性AP患者的疗效和安全性.
- 为了比较NFD和LFD组之间的能量摄入量,QoL,并发症,停留时间和再录取率.
主要方法:
- 一项随机对照研究招募了从2022年7月到2023年4月的患者.
- 参与者被分配到NFD (30%脂肪) 或LFD (15%脂肪) 中.
- 主要结局是每天的能量摄入量;次要结局包括QoL,并发症,停留时间和90天的再入院.
主要成果:
- 在NFD组的第一天和第二天,以及营养不良的子组中,能量摄入量显著增加.
- 总体能量摄入量在各组之间没有显著差异.
- 在物理和心理领域,NFD导致了显著更高的QOL分数.
- 在腹部疼痛,甘油三水平,感染,停留时间或再入院率方面没有发现显著差异.
结论:
- 在轻度至中度AP患者中,NFD与较高的初始热量摄入量和改善的QoL有关,而不会增加不良事件.
- 对于非高甘油三血性AP,可能不需要常规的LFD处方.
- 对于这些患者来说,NFD是一个可行的,可能更有益的饮食选择.
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