一个新的工具来研究子宫内药物暴露对儿童神经发育的影响
Laurane Delteil1, Caroline Hurault-Delarue1, Catherine Arnaud2
1Réseau Regards, pharmacologie médicale et clinique, centre hospitalier universitaire de Toulouse, Inserm UMR 1295 CERPOP Equipe SPHERE, université de Toulouse, 31000 Toulouse, France.
概括
这项研究将产前药物暴露与儿童神经发育障碍联系起来. 暴露于某些药物的儿童,特别是那些影响神经系统的药物,患自闭症和严重残疾等疾病的风险更高.
科学领域:
- 药学流行病学 药学流行病学
- 神经发育障碍 神经发育障碍
- 药品安全 药品安全
背景情况:
- 评估子宫内药物暴露对儿童发育的风险至关重要.
- 现有的数据库往往缺乏关于药物暴露和儿童长期结果的全面数据.
- 埃菲梅里斯数据库收集了怀孕期间的药物数据,但需要与儿童残疾数据进行链接.
研究的目的:
- 实施一种新的工具,用于评估产前药物暴露导致的严重残疾风险.
- 将EFEMERIS数据库与高加隆地区儿童残疾登记处 (RHE31) 的数据进行丰富.
- 调查产前药物暴露与儿童神经发育障碍之间的潜在关联.
主要方法:
- 将EFEMERIS数据库 (97,350名儿童,2004年至2014年出生) 与RHE31注册表联系起来.
- 确定了908名患有普遍发育障碍 (PDD) /自闭症谱系障碍 (ASD) 和/或严重智力障碍 (IQ<50) 的儿童.
- 在被诊断为残疾和没有残疾的儿童之间比较药物暴露概况.
主要成果:
- 患有PDD/ASD和/或严重残疾的儿童显著更有可能在产前接触某些药物类别.
- "神经系统"类药物显示出与增加风险的显著关联.
- 在匹配和非匹配的RHE31合格儿童之间没有观察到显著的差异.
结论:
- 综合数据库可以对产前药物效应和儿童神经发育进行药学流行病学研究.
- 这项法国倡议是改善药物对儿童神经发育影响数据的先驱.
- 这些发现表明需要对特定药物类别和神经发育结果进行进一步研究.
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