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Updated: Sep 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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一个多重分割和混合平台,用于各种有针对性的蛋白质降解

Yuechen Wang1, Qinhong Luo1, Yun Xing1

  • 1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

ACS chemical biology
|August 20, 2025
PubMed
概括

一个新的Multi-SM-PROTAC平台可以同时降解多个蛋白质标. 这种双功能分子方法简化了针对无法治疗的目标的复杂药物开发,在癌症治疗中显示出前景.

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