Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

4.0K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
4.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

334
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
334
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

2.5K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Degeneration of Interpericyte Tunneling Nanotubes Can Occur in the Absence of Pericyte Loss in Diabetic Retina Disease.

Investigative ophthalmology & visual science·2026
Same author

Predicting the progression of proliferative diabetic retinopathy: Pathophysiology, imaging phenotypes, and determinants of disease persistence despite therapy.

Survey of ophthalmology·2026
Same author

Expert consensus on fundus fluorescein angiography reporting in ophthalmology: a Delphi study.

The British journal of ophthalmology·2026
Same author

Rethinking the Long-Term Degradation of Crosslinked Gelatin Stents: Response.

Clinical & experimental ophthalmology·2026
Same author

Evidence for the Existence of Two Opposing Pulse Waves in Retinal Vein Segments Within the Optic Disc.

Investigative ophthalmology & visual science·2025
Same author

Interpericyte tunnelling nanotube loss in very early diabetic retinal disease.

Diabetologia·2025
Same journal

MT-MRI for detection of renal interstitial fibrosis in renovascular disease.

Scientific reports·2026
Same journal

Detection of underground objects from GPR data using a lightweight YOLO-based approach.

Scientific reports·2026
Same journal

Early systemic inflammatory-metabolic trajectory phenotypes are associated with survival outcomes in metastatic renal cell carcinoma treated with nivolumab.

Scientific reports·2026
Same journal

Water balance components in a dry-seeded rice-wheat system: Untangling the effects of tillage and mulching practices.

Scientific reports·2026
Same journal

Topological approaches to quantum tensor train compression via ZX-calculus and SVD.

Scientific reports·2026
Same journal

determinants of flood impacts and adaptive capacity among market vendors in Walukuba-Masese, Jinja city, Uganda.

Scientific reports·2026
查看所有相关文章

相关实验视频

Updated: Sep 10, 2025

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.8K

内皮功能可以通过急性高血糖调节.

Hassanain Qambari1,2, Paula K Yu1, Chandrakumar Balaratnasingam1,2

  • 1Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia.

Scientific reports
|August 20, 2025
PubMed
概括
此摘要是机器生成的。

急性高血糖暂时增强眼内皮功能,但在糖尿病老鼠长期暴露导致不完全恢复,表明不可逆转的功能障碍. 这会影响微血管疾病的发展.

关键词:
急性高血糖症是什么意思内皮质功能障碍 内皮质功能障碍血糖控制 血糖控制 血糖控制链毒素诱导的糖尿病血管疾病是血管疾病.

更多相关视频

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

5.0K
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.6K

相关实验视频

Last Updated: Sep 10, 2025

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.8K
Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

5.0K
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.6K

科学领域:

  • 眼科医生 眼科 眼科
  • 内分泌学 在内分泌学.
  • 血管生物学 血管生物学

背景情况:

  • 慢性高血糖的内皮功能障碍有助于微血管疾病,如糖尿病视网膜病变.
  • 血管内皮在急性高血糖症中的影响和恢复还不清楚.

研究的目的:

  • 为了研究急性和长期高血糖症对眼部微血管内皮功能和康复的作用,在斯特佐素 (STZ) 诱导的糖尿病大鼠中.
  • 评估组织学变化,包括毛细血管密度,直径,细胞周围细胞分布,eNOS和高级糖化最终产品 (AGEs).

主要方法:

  • 从正常血糖和1至4周的STZ-糖尿病大鼠中分离过的眼睛制剂.
  • 顺序 perfusion 与不同的葡萄糖度 (6 mM, 12 mM, 24 mM, 然后 6 mM).
  • 测量乙胆 (Ach) 诱导的血管扩张反应和组织学检查.

主要成果:

  • 在所有组中,急性高葡萄糖增强了Ach诱导的血管扩张.
  • 在恢复正常血糖症后,在1至3周的糖尿病眼睛中观察到Ach反应的恢复.
  • 4周的糖尿病眼睛表现出持续增强的血管扩张,尽管正常血糖.
  • 在3周和4周的糖尿病眼中增加细胞周分布;在1周的糖尿病眼中增加eNOS;在1周的糖尿病眼中检测到AGE.

结论:

  • 短期高血糖症可以恢复内皮功能.
  • 糖尿病大鼠的长期高血糖症 (≥4周) 会导致功能恢复不完全,表明潜在的转向不可逆转的内皮功能障碍.
  • 这些发现强调了高血糖引起的眼睛血管损伤的渐进性.