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基于与CA153的PiRNA表达的乳腺癌早期诊断的机器学习模型

Limin Niu¹, Weicheng Zhou², Xiao Li¹

¹Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440#, Jinan, 250117, Shandong, PR China.

Scientific reports

|August 20, 2025

概括

循环中的PIWI相互作用RNAs (piRNAs) 在早期发现乳腺癌方面表现有前途. 一个机器学习模型将tri-piRNA签名与CA153结合起来,实现了卓越的诊断准确性.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
生物信息学是一种生物信息学.

背景情况:

与PIWI相互作用的RNAs (piRNAs) 在癌症发展中发挥作用.
循环中的piRNAs是癌症检测的潜在生物标志物.

研究的目的:

调查循环piRNAs对于乳腺癌 (BC) 的诊断效用.
开发和验证用于早期BC诊断的机器学习 (ML) 模型,使用piRNA签名和临床因素.

主要方法:

血清piRNA测序发现了一个三-piRNA签名 (piR-139966,piR-2572505,piR-2570061).
定量PCR (qPCR) 验证的piRNA表达水平.
机器学习算法被用于构建集piRNA数据与CA153水平的预测模型.

主要成果:

在早期的BC患者中,已识别的tri-piRNA签名显著上调.
皮RNA小组提高了BC检测的诊断精度,补充了CA153.
一个基于XGBoost的ML模型整合了piRNA表达和CA153,证明了早期BC识别的最佳性能.

结论:

循环piRNAs代表了对非侵入性早期乳腺癌诊断的有希望的生物标志物.
机器学习框架可以有效地整合多模式数据 (piRNA和CA153) 以提高BC诊断准确性.

关键词:

乳腺癌乳腺癌乳腺癌早期诊断早期诊断早期诊断机器学习模型机器学习模型与PIWI相互作用的RNAs (piRNAs) 发生相互作用.在XGBoost算法中使用的算法.

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相关概念视频

piRNA - Piwi-interacting RNAs

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...