Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Progression of radial tears in L5-S1 intervertebral disc depends on location and type of movements: An in-silico study.

PloS one·2026
Same author

Deep learning-driven optimization and predictive modeling of LASER beam machining for XG3 steel.

Scientific reports·2026
Same author

Stress evaluation along the posterior annular circumferential tears on the L5-S1 spinal unit as an index of tear progression.

Journal of orthopaedics·2025
Same author

Chemical characterization of hibiscus rosa-sinensis plant fibers facilitated through design of experiments and artificial neural network hybrid approach.

Scientific reports·2024
Same author

Processing, Characterization of <i>Furcraea foetida</i> (FF) Fiber and Investigation of Physical/Mechanical Properties of FF/Epoxy Composite.

Polymers·2022

相关实验视频

Updated: Jun 4, 2026

Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.2K

使用直角数组驱动的FEA和神经网络建模的3D打印骨架的计算优化.

Amulya Shetty1, Aamirah Fathima1, B Anika1

  • 1Father Muller Medical College, Mangalore, Karnataka, 575002, India.

Scientific reports
|August 20, 2025
PubMed
概括

这项研究优化了用于骨组织工程的3D打印多乳酸 (PLA) 脚手架. 厚度为2.0毫米的Gyroid格子几何结构提供了卓越的机械性能,由AI和模拟验证.

关键词:
增材制造的脚手架是使用增材制造的.人工神经网络的人工神经网络骨组织工程 骨组织工程有限元素分析的研究.机械表征 机械表征微观结构分析 微观结构分析软计算技术是一种软计算技术.塔古奇设计的实验设计.

更多相关视频

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

6.6K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.0K

相关实验视频

Last Updated: Jun 4, 2026

Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.2K
3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

6.6K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.0K

科学领域:

  • 生物材料科学 生物材料科学
  • 整形外科工程 整形外科工程
  • 组织工程是组织工程.

背景情况:

  • 骨组织工程旨在利用仿生支架和先进材料再生受损的骨.
  • 优化脚手架设计对于机械完整性和骨再生中的生物性能至关重要.

研究的目的:

  • 优化用于骨组织工程应用的3D打印的多乳酸 (PLA) 格子支架.
  • 研究几何配置和加工参数对脚手架机械性能的影响.

主要方法:

  • 发展了具有不同壁厚 (1.0-2.0毫米) 的利迪诺型,钻石型和陀螺型格子支架.
  • 塔古奇L27直角阵列在压力负载 (3-9 kN) 下用于实验设计和机械测试的应用.
  • 使用逆向传播人工神经网络 (BPANN) 进行预测建模和有限元分析 (FEA) 进行验证.

主要成果:

  • 厚度为2.0毫米的Gyroid网格表现出卓越的机械完整性,在3kN时表现出最小的位移 (0.36毫米) 和应变 (1.2x10-2).
  • 在测试条件下,lidinoid结构显示出最高的变形性.
  • 对于脚手架的位移和应变,BPANN模型实现了高预测准确度 (R2 > 0.995).

结论:

  • 由于其增强的机械性能,Gyroid格子几何学代表了骨组织工程的有前途的支架设计.
  • 结合实验设计,机器学习和FEA的综合方法为优化脚手架架构提供了一个强大的框架.
  • 优化的脚手架对改善骨愈合应用中的机械强度和生物结果具有重要意义.