神经阻塞辅助的肌内注射特兰克萨胺酸,维生素C和谷氨治疗梅拉斯马:一个分裂面对比较研究
Hongru Zhou1, Yu Yao1, Yuejie Zhou2
1Center for Cleft Lip and Palate Treatment, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, China.
Aesthetic plastic surgery
|August 20, 2025
概括
在神经阻塞下进行皮内注射的三胺酸 (TXA),维生素C和谷氨,有效地治疗梅拉斯马,并减少疼痛. 这种组合疗法为管理多颜色障碍提供了安全和改进的选择.
科学领域:
- 皮肤病学 皮肤病学
- 化品科学 化品科学
背景情况:
- 黑色素是一种普遍的色素疾病,导致对称的多色素.
- 目前用于治疗黑色素的组合疗法,包括胺酸 (TXA),维生素C和谷氨,已显示出局限性.
研究的目的:
- 评估TXA,维生素C和谷氨通过神经阻塞进行内皮注射的疗效和安全性,用于治疗瘤.
- 为了比较局部麻醉和神经阻断方法之间的疼痛水平.
主要方法:
- 一项前性,分脸试验涉及20名乳腺癌患者.
- 与局部利多卡因相比,对神经阻塞 (内耳道和肌面部) 进行了比较.
- 皮内TXA,维生素C和谷氨被两周一次给药,持续8周.
- 治疗前和治疗后三个月评估了疗效和疼痛.
主要成果:
- 维西亚分析显示,紫外线和棕色斑点的显著改善.
- 修改的梅拉斯马区域和严重性指数 (mMASI) 得分显著下降 (P < 0.001).
- 神经阻塞方面报告的疼痛得分明显低 (VAS 2.50 ± 0.83),比局部麻醉方面 (VAS 4.35 ± 1.22) (P < 0.001).
- 没有观察到任何严重的不良事件.
结论:
- 在神经阻塞下注射TXA,维生素C和谷氨的皮内注射是一种安全有效的黑色素治疗方法.
- 这种方法提供了一个低疼痛的替代方法来管理瘤.
- 组合疗法在改善多发色素和患者舒适性方面表现有前途.
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