胃肠道症状在新发性耐火状态 (NORSE) 患者中很常见
Anima Shrestha1, Lori J Silveira2, Divya Thomas3
1University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, USA. anima.shrestha@cuanschutz.edu.
概括
胃肠道症状在新发性耐火性状态 (NORSE) 和发烧性感染相关综合征 (FIRES) 中很常见,在一些患者中在出院后持续存在. 治疗强度,而不是疾病持续时间,与胃肠道问题相关.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 新发性耐火性状态 (NORSE) 是一种罕见的疾病,其特征是没有明确原因的耐火性发作.
- 发烧性感染相关综合征 (FIRES) 是NORSE的一个子集,前面是发烧性疾病.
- 在NORSE患者中,长期的严重疾病和治疗可能导致胃肠道 (GI) 障碍.
研究的目的:
- 在被诊断为NORSE的患者中描述胃肠道症状的发生率和性质.
- 在初次住院治疗后,调查胃肠道症状的持续性.
- 探索NORSE患者的胃肠道症状和临床因素之间的潜在关联.
主要方法:
- 一个多中心的回顾性研究,涉及NORSE患者.
- 数据收集包括初始住院和后续信息.
- 使用R-4.2.1.2.1.进行统计分析.
主要成果:
- 89%的NORSE患者在住院期间经历了胃肠道症状,最常见的是吐 (79%),便秘 (73%) 和腹痛 (47%).
- 在平均37个月的随访后,在幸存的患者中,31%的人仍然报告了GI症状.
- 增加抗发作药物的数量和更高的巴比塔尔率与胃肠道症状有关.
结论:
- 胃肠道症状是NORSE患者在住院期间经常出现的并发症,并在出院后可能持续存在.
- 由于意识改变而导致的胃肠道症状的潜在报告不足是一个限制.
- 需要进一步的研究来确定胃肠道症状是否是严重疾病的次要因素,还是NORSE病原体的一部分.
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