暴露于多环芳和感染人类乳头瘤病毒和2型简单疹病毒之间的关联
Shuping Yang1, Yingjing Wu1, Qi Ding1
1School of Public Health, Wannan Medical College, 22 Wenchang West Road, Yijiang District, Wuhu, Anhui, China.
Scientific reports
|August 20, 2025
概括
暴露于多环芳 (PAHs) 与美国女性感染人乳头瘤病毒 (HPV) 和简单疹病毒2型 (HSV-2) 感染率较高有关. 这项研究强调了环境污染物和生殖道感染之间的潜在联系.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAH) 是常见的环境污染物.
- 人类乳头瘤病毒 (HPV) 和2型简单疹病毒 (HSV-2) 是普遍存在的生殖道感染.
研究的目的:
- 调查美国成年女性同时暴露于PAHs和HPV或HSV-2感染之间的关联.
- 探索PAH联合暴露对感染患病率的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 中对4,284名成年女性进行横截面分析.
- 后勤回归和加权量积回归 (WQS) 用于评估单个和组合PAH暴露和感染结果之间的关联.
- 根据年龄,种族,社会经济地位和吸烟状况等各种共同变量进行了调整.
主要成果:
- 在特定的PAH (如2-NAP,1-PHE,1-PYR) 和HPV感染之间发现了积极的关联.
- 一些PAHs (例如,1-NAP,3-FLU,1-PHE,1-PYR) 与HSV-2感染有关.
- WQS回归表明,联合PAH暴露增加了HPV感染 (OR=1.29) 和HSV-2感染 (OR=1.81) 的几率,其中纳夫托是显著的贡献者.
结论:
- 暴露于PAH与女性HPV和HSV-2感染的更高患病率有关.
- 这些发现表明,环境PAH暴露和生殖道感染之间存在潜在的流行病学联系.
- 需要进一步的研究来证实这些关联并阐明潜在的机制.
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