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TCF1 和 LEF1 促进 B-1a 细胞平衡和调节功能

Qian Shen1, Hao Wang2, Jonathan A Roco2,3

  • 1Francis Crick Institute, London, UK. qian.shen@crick.ac.uk.

Nature
|August 20, 2025
PubMed
概括

转录因子TCF1和LEF1对于B-1a细胞的调节至关重要,维护它们的干细胞性质和免疫功能. 这些因子的丧失会损害B-1a细胞的维持和调节能力,影响炎症控制.

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