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mAChR4通过GAP诱导的抗菌免疫抑制肝病

Cristina Llorente1, Fernanda Raya Tonetti2, Ryan Bruellman2

  • 1Department of Medicine, University of California San Diego, La Jolla, CA, USA. allorenteizquierdo@health.ucsd.edu.

Nature
|August 20, 2025
PubMed
概括

长期使用酒精会通过减少杯细胞抗原通道 (GAPs) 破坏肠道免疫力. 通过阻断细菌转移,激活特定的受体恢复了GAP,从而预防了与酒精有关的肝病 (ALD).

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...