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在COVID-19患者中患有超血症:胰腺干扰还是次要的表现?
Marcello Candelli1,2, Roberta Calce3, Giulia Pignataro4
1Emergency, Anesthesiological and Reanimation Sciences Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS of Rome, 00168, Rome, Italy. marcello.candelli@policlinicogemelli.it.
COVID-19 患者血清氨酶升高通常表明疾病的严重程度,而不是胰腺炎. 超血症与重症监护室 (ICU) 住院有关,强调需要在急诊室进行更密切的监测.
科学领域:
- 传染性疾病
- 胃肠病学
- 危急护理医学
背景情况:
- 血清氨酶升高在COVID-19患者中很常见,但其原因 (胰腺与其他机制) 尚不清楚.
- 胰腺炎和COVID-19严重程度之间的关系需要进一步调查.
研究的目的:
- 调查高甲血症,胰腺炎和COVID-19严重程度之间的关联.
- 确定血清氨酶升高是否预测COVID-19患者的严重结果.
主要方法:
- 在Fondazione Policlinico Gemelli-IRCCS住院的1858名COVID-19患者的回顾性分析.
- 收集的临床和实验室数据,包括血清氨酶,急症室入院和死亡率.
- 使用单变量和多变量逻辑回归来分析关联.
主要成果:
- 超胺血症与高血尿,ICU入院,并发症和D-二次体相关.
- 多变量分析证实了高胺血症和重症监护室入院之间的独立关联 (而不是死亡率).
- 只有四名患者被诊断为急性胰腺炎.
结论:
- 在COVID-19中血清氨酶的升高比直接的胰腺参与更能表明疾病的严重程度.
- 紧急病房COVID-19患者的超血可能表明ICU入院的风险增加.
- 应急医生应将高胺血症作为患者更密切的评估和管理的标志物.
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