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Tingyuan Zeng¹, Jianqin Cheng², Yu Pan²

¹Guizhou University Medical College, Guiyang, Guizhou Province, 550025, China.

BMC microbiology

|August 21, 2025

概括

肠道微生物群和代谢物变化与阻塞性睡眠呼吸暂停 (OSA) 的严重程度有关. 这些由慢性间歇性缺氧 (CIH) 引起的变化可以作为诊断和评估OSA的新生物标志物.

科学领域:

微生物学
代谢学
睡眠医学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的睡眠障碍.
人们越来越认识到肠道微生物在OSA病变中的作用.
慢性间歇性缺氧 (CIH) 是OSA的一个标志,可能会影响肠道健康.

研究的目的:

在阻塞性睡眠呼吸暂停 (OSA) 中调查肠道微生物群和代谢物概况.
评估这些特征作为OSA诊断和严重性的生物标志物.
探索慢性间歇性缺氧 (CIH) 中肠道变化和临床指标之间的相关性.

主要方法:

在OSA和CIH小鼠模型中利用16S rRNA测序和向代谢.
分析了肠道微生物的组成和功能.
评估了临床指标,OSA严重程度和肠道菌群/代谢物之间的关联.

主要成果:

OSA和CIH组表现出肠道微生物群的变化,Firmicutes和Tenotrophomonas的增加,以及Bacteroidota和Ligilactobacillus的减少.
在OSA和CIH组中观察到Nervonic acid和Erucic acid水平升高,同时Arachidonic acid水平降低.
在特定细菌 (例如,Coprobacillus,Bacteroidota,Lactococcus) 和临床指标 (例如,淋巴细胞,eosinophilia,中性粒细胞,AHI) 之间发现了显著的相关性.

结论:

慢性间歇性缺氧 (CIH) 诱导显著的肠道微生物和代谢物失调.
这些肠道变化与OSA临床指标和疾病严重程度相关.
肠道微生物群和代谢物显示为用于OSA诊断和评估的新生物标志物.

关键词:

生物标志物慢性间歇性缺氧疾病评估肠道微生物群有针对性的代谢组学

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