结合正念干预和慢性疼痛的开放性安慰剂治疗:可行性研究的方案
Chung Jung Mun1,2, Estrella Contreras3, Yushu Xiao3
1Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, 85004, USA. ChungJung.Mun@asu.edu.
Pilot and feasibility studies
|August 21, 2025
概括
这项研究探讨了将正念 (MBSR) 与开放式安慰剂 (OLP) 结合起来治疗慢性疼痛. 这项研究评估了这种新型疼痛管理方法的可行性和可接受性.
科学领域:
- 心灵与身体的医学
- 治疗疼痛
- 临床试验研究
背景情况:
- 基于正念的压力减轻 (MBSR) 有效地治疗慢性疼痛,但效果很小.
- 冥想可能无法激活内源性阿片类系统,
- 开放式安慰剂 (OLP) 有望缓解疼痛,可能通过内源性阿片类药物释放.
研究的目的:
- 评估结合MBSR和OLP治疗慢性疼痛的可行性和可接受性
- 将联合干预与单独的MBSR和单独的OLP进行比较
- 为未来的慢性疼痛治疗大规模疗效试验提供信息.
主要方法:
- 一个三臂随机对照试验 (RCT) 涉及8周的干预.
- 参与者接受了仅MBSR,仅OLP或MBSR+OLP联合治疗.
- 通过遵守监测 (电子盖,尿液测试) 和每日日记来评估可行性.
主要成果:
- 这个部分在提供的摘要中没有.
- 这个部分在提供的摘要中没有.
- 这个部分在提供的摘要中没有.
结论:
- 这些发现将指导未来的全功率多站点疗效试验.
- 这项研究提供了关于新型联合疼痛治疗的可行性和可接受性的重要数据.
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