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Pelin Eroğlu¹, Mehmet Ulaş Civaner², Selda Doğan Çalhan³

¹. pelineroglu5@gmail.com.

Acta chimica Slovenica

|August 21, 2025

概括

来自特有植物Onosma mutabilis的乙醇提取物具有显著的抗氧化和抗菌特性. 这项研究详细介绍了其含量,生物活性化合物以及对A. baumannii的有效性.

科学领域:

药物鉴定和植物化学
自然产品化学

背景情况:

这种属属属于菜科,以其丰富的植物化学物质和治疗潜力而闻名.
关于Onosma mutabilis Boiss的特征和药用性质的科学数据有限. 没有人知道. 现在我们已经知道了. (O. mutabilis) 的一个.

研究的目的:

研究来自O. mutabilis各部分 (叶子,茎,根,花) 的乙醇提取物的总含量,抗氧化活性,生物活性化合物和抗菌作用.
建立对O. mutabilis的化学特征和潜在的药理应用的基本理解.

主要方法:

使用酸等价物 (GAE) 量化总含量.
通过1,1-二-2-皮克里尔 (DPPH) 试验和降低抗氧化能力 (CUPRAC) 试验评估抗氧化活性,分别报告IC50和特洛克斯等效 (TE).
使用气色谱与质谱 (GC/MS) 结合识别生物活性化合物.
使用最小抑制度 (MIC) 值对抗Acinetobacter baumannii的抗菌活性的评估,与安皮西林相比.

主要成果:

植物不同部位的含量在9.2至31mg/g的提取物之间.
抗氧化能力显示IC50值在4. 3929μg/ ml (DPPH) 和0. 450. 78 mmol TE/ g (CUPRAC) 之间.
在GC/MS分析中发现了29种不同的化学成分.
所有O. mutabilis提取物对A. baumannii具有显著的抗菌活性,MIC值为62.5μg/ ml,超过了参考药物安皮西林 (125μg/ ml).

结论:

菌具有显著的化合物含量,并表现出显著的抗氧化和抗菌活性.
乙醇提取物含有多种生物活性化合物,有助于其观察到的药理作用.
O. mutabilis是天然化合物的有希望的来源,具有潜在的治疗用途,特别是作为对抗A. baumannii的抗菌剂.

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