合成,晶体结构和抗菌活性N,N'-Bis(4-bromosalicylidene) -1,2-及其铜(II) 复合物
1Baicheng Normal University. jyxygzb@163.com.
Acta chimica Slovenica
|August 21, 2025
概括
研究人员合成了一种新的bis-Schiff基联体和两种铜 (II) 复合物. 这些化合物对常见病原体的抗菌和抗真菌活性进行了评估.
科学领域:
- 协调化学
- 无机化学
- 抗菌研究
背景情况:
- 希夫基是协调化学中的多功能连接体.
- 铜复合体通常表现出显著的生物活性.
- 由于耐药性日益增加,开发新的抗菌剂至关重要.
研究的目的:
- 合成和描述一个新的bis-Schiff基联体及其铜 (II) 复合物.
- 研究合成复合物中的铜的协调环境.
- 评估合成化合物的抗微生物和抗真菌潜力.
主要方法:
- 合成N,N'-bis-bromosalicylidene-propane-1,2-diamine (H2L) 和其铜-II复合物.
- 使用光谱方法进行表征 (例如,UV-Vis,IR).
- 通过单晶X射线衍射进行结构阐明.
- 对黄金葡萄球菌和大肠杆菌的抗菌活性测定.
- 对Candida parapsilosis的抗真菌活性进行检测.
主要成果:
- 成功合成和表征bis-Schiff基H2L和两个铜 (II) 复合物:单核[CuL] (1) 和四核[Cu4Cl2L2 (N3) 2]·CH3OH (2).
- X射线衍射揭示了复合1中的正方形平面协调和复合2中的混合正方形平面/正方形金字塔协调.
- 预先查表明该联体及其复合物的潜在抗菌和抗真菌活性.
结论:
- 合成的bis-Schiff基及其铜复合体具有有趣的结构多样性.
- 铜复合物显示出作为抗菌剂的潜力.
- 需要进一步的研究来探索它们的治疗用途.
更多相关视频
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
6.4K
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
9.7K
相关概念视频
01:20Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
2.0K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
2.0K
02:34Structural Isomerism
19.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.7K
01:19Diazonium Group Substitution: –OH and –H
2.9K
Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
2.9K
02:52Stereoisomerism
12.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.4K
01:11Aryldiazonium Salts to Azo Dyes: Diazo Coupling
3.1K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
3.1K
01:14Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
2.2K
Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
2.2K