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相关概念视频

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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使用时间依赖的扩散MRI区分良性甲状腺结节和乳头甲状腺癌:可行性研究

Huanhuan Ren1, Diwei Shi2,3, Junhao Huang1

  • 1Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China.

Journal of magnetic resonance imaging : JMRI
|August 21, 2025
PubMed
概括

时间依赖的扩散MRI (td-dMRI) 参数,包括瘤大小和细胞性,可以帮助区分良性和恶性甲状腺结节. 将td-dMRI与TI-RADS分类系统相结合,可显著提高皮质甲状腺癌 (PTC) 的诊断准确度.

关键词:
诊断情况扩散核磁共振甲状腺

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科学领域:

  • 放射学和医学成像
  • 癌症学
  • 生物物理

背景情况:

  • 准确区分良性和恶性甲状腺结节对于有效的治疗计划和预后至关重要.
  • 目前的诊断方法没有理想的方法来区分良性和恶性甲状腺结节.

研究的目的:

  • 评估依赖时间的扩散MRI (td-dMRI) 导出的微结构参数在准确区分良性和恶性甲状腺结节中的有效性.
  • 将 td-dMRI 参数的诊断性能与现有的分类系统进行比较.

主要方法:

  • 一项前性,单中心研究,涉及232名患有病态诊断的甲状腺结节的参与者.
  • 使用3.0 T td-dMRI与振荡和脉冲梯度旋转回声序列.
  • 使用回归模型分析临床因素和td-dMRI参数 (例如细胞性,瘤大小);开发和比较TI-RADS,组合和综合模型.

主要成果:

  • 从td-dMRI获得的瘤大小和细胞性独立地与恶性甲状腺结节相关.
  • 与单独使用TI- RADS (AUC: 0. 891) 相比,结合瘤最大直径,细胞性和TI- RADS的组合模型显著提高了诊断准确度 (AUC: 0. 941).
  • 综合模型显示了综合歧视改善 (IDI) 和净重新分类改善 (NRI) 的实质性改进.

结论:

  • 结合 td-dMRI 和 TI-RADS 的瘤最大直径和细胞度的综合模型显示出区分良性甲状腺结节与乳头甲状腺癌 (PTC) 的显著潜力.
  • 这种方法提供了更高的诊断准确性,有助于更精确的患者管理.