评估患有喘儿童菌的新生物标志物
Lalith K Silva1, Cody A Newman1, Idris J Wazeerud-Din1
1Division of Laboratory Sciences, National Center for Environmental Health, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
概括
血清二是最近家庭菌暴露的一个有前途的生物标志物. 这一发现支持对室内菌及其健康影响的公共卫生调查,特别是在脆弱的社区.
科学领域:
- 环境健康
- 生物标志物发现
- 毒理学
背景情况:
- 家庭菌是一个重要的环境健康问题,特别是在风或洪水等自然灾害之后.
- 在家里入水可能会导致菌生长,对居住者的健康构成风险.
- 需要一个可靠的室内菌暴露生物标志物来帮助公共卫生调查.
研究的目的:
- 在患有喘的儿童中确定最近室内菌的潜在生物标志物.
- 调查家庭菌与水损伤以及血清中的特定微生物挥发性有机化合物 (mVOC) 之间的联系.
主要方法:
- 在132名患有喘的儿童血清样本中,使用气色谱-质谱 (GC-MS) 分析了6种mVOC.
- 使用回归分析评估报告的菌/水损伤与mVOC水平之间的关联.
- 测量了尿液中的素,以评估室内烟雾作为潜在的混因子.
主要成果:
- 据报道,生活在有菌或水损伤的家庭的儿童的血清二松度显著提高 (32%的增加).
- 尿液中较高的可提宁水平 (表明更高的烟草烟雾暴露) 与血清二甲基醇水平的升高有关.
- 报告的室内烟草吸烟与较高的血清二甲基-1-醇水平有关.
结论:
- 血清二是最近家庭菌暴露的一个有前途的生物标志物.
- 可检测的mVOC指数也显示出菌暴露的生物标志物.
- 这些生物标志物可以补充公共卫生环境中评估菌暴露的现有方法.
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