在儿童和青少年膝盖受伤的试验中报告的结果:一个系统性审查
Ignatius Liew, Wen Xian Low1, Adeel Ikram2,3
1Queen Mary University of London, London, UK.
Bone & joint open
|August 21, 2025
概括
儿童膝关节损伤的结果报告缺乏标准化,没有确立的核心结果集. 制定一致的措施对于未来的研究和改善儿童骨科患者护理至关重要.
科学领域:
- 骨科和体育医学
- 儿童健康
- 临床试验方法
背景情况:
- 膝盖受伤在儿童和青少年中很常见,但临床试验中的结果报告不一致.
- 现有研究缺乏标准化结果,阻碍了研究结果的可比性和综合性.
- 世界卫生组织的功能,残疾和健康国际分类 (ICF) 提供了分类健康结果的框架.
研究的目的:
- 系统地审查和绘制有关儿童膝关节损伤的已发表试验报告的结果.
- 确定儿科膝关节损伤研究中使用的结果指标的可变性和一致性.
- 突出需要标准化结果报告和核心结果集 (COS) 的发展.
主要方法:
- 在多个数据库 (MEDLINE,Embase,Cochrane CENTRAL,Clinicaltrials.gov,WHO ICTRP) 进行了全面的搜索,截至2024年7月.
- 根据PRISMA指南进行查和数据提取后,最终包括了15项研究.
- 报告的结果与世界卫生组织的ICF框架领域 (身体功能,活动和参与,环境因素,身体结构) 相匹配.
主要成果:
- 从15项试验中,共确定了35个ICF领域的83个结果.
- 最常报告的ICF领域包括下肢结构 (s750),疼痛感 (b280),关节运动 (b710),骨/关节功能 (b729).
- 只有13. 3%的试验报告了患者满意度,而46. 6%的试验没有主要结果. 儿童IKDC是患者报告的最常见的结果指标.
结论:
- 儿童和青少年膝关节损伤的结果测量工具存在显著的变化和不一致.
- 由于没有确定的核心结果集 (COS),因此迫切需要改善试验报告的标准化和一致性.
- 未来的COS开发应纳入病理特异性的子类别,以解决不同膝关节损伤领域对ICF领域的不同重视,确保全面和特定条件的优先级.
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