在小鼠中通过cIAP1/2调节TNF信号通路缓解大肠炎
Ting Liu1, Qiang Meng1, Yijun Zhang1
1College of Food Science and Technology, Northwest University, Xi'an, Shaanxi, 710069, China. mengqiang@nwu.edu.cn.
Food & function
|August 21, 2025
概括
在HA-SH水凝中封装的Corynebacterium glutamicum通过减少炎症和恢复肠道微生物群平衡,有效治疗性结肠炎 (UC). 这种益生菌疗法针对TNF和NF- kB信号通路,以获得治疗效益.
科学领域:
- 微生物学和免疫学
- 胃肠病学
- 生物材料科学
背景情况:
- 性结肠炎 (UC) 与肠道微生物群失调有关.
- 已知Corynebacterium glutamicum可以在其他疾病中恢复肠道活化.
- 对于UC的C. glutamicum的治疗潜力仍未得到探索.
研究的目的:
- 研究C. glutamicum对性结肠炎 (UC) 的治疗作用.
- 阐明C. glutamicum在缓解UC炎症中的潜在机制.
- 评估C. glutamicum在化氨酸 (HA-SH) 水凝 (CG-HA-SH) 中封装的疗效.
主要方法:
- 在HA-SH中封装C. glutamicum以形成CG-HA-SH水凝.
- 评估CG-HA-SH的肠粘附和分布.
- 在UC小鼠模型中评估治疗效果,包括肠道微生物群分析,短链脂肪酸 (SCFA) 分析和RNA测序 (RNA-Seq).
主要成果:
- 在约12小时内,CG-HA-SH在炎症部位表现出持续的粘附.
- C. glutamicum显著降低了促炎细胞因子 (IL-1β,TNF-α) 和增加了抗炎IL-10.
- 治疗调节了肠道微生物群,增加了有益的SCFA (丁酸盐),增强了肠道紧接点 (OCC) 和粘液屏障 (MUC2),并通过TNF和NF- kB信号通路降低了cIAP1/ 2的表达.
结论:
- 在缓解UC炎症和重塑肠道微生物群方面,C. glutamicum具有显著的治疗效果.
- 该机制涉及对cIAP1/ 2介导的TNF和NF- kB信号通路的下调.
- cIAP1和cIAP2是UC治疗的潜在治疗点.
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