MASLD药疗:当前标准,新兴治疗方法和印度医生的实用指南
1Professor, Department of Gastroenterology, Institute of Liver, Gastroenterology, and Pancreatico-Biliary Sciences, Sir Ganga Ram Hospital, Delhi, India, Corresponding Author, Orcid: https://orcid.org/0000-0001-6680-7227.
The Journal of the Association of Physicians of India
|August 21, 2025
概括
印度正在开发针对肝脏脂肪和炎症的新药来治疗与代谢功能障碍相关的脂肪性肝病 (MASLD). 这篇评论为印度医生提供了有关MASLD当前和新兴药物选择的实用指导.
科学领域:
- 肝病和代谢疾病
- 药理学和药物开发.
- 公共卫生和流行病学.
背景情况:
- 由于肥胖和2型糖尿病 (T2DM) 的增加,肥胖性肝病 (MASLD) 已成为越来越严重的全球健康问题.
- 从简单的肥胖症到有纤维化的MASH, 增加肝硬化,肝癌和心血管疾病的风险.
- 生活方式的改变是首要的,但药物干预对于渐进的MASLD或高风险患者至关重要.
研究的目的:
- 提供对现有和新兴的MASLD药物治疗方法的全面审查.
- 为管理MASLD的印度医生提供实用,基于证据的建议.
- 提供针对印度环境而定制的非肝炎性MASLD (F0-F3纤维化) 的结构化治疗算法.
主要方法:
- 对MASLD的药理学药物的最新临床试验数据的审查.
- 对针对MASLD关键途径 (肥胖症,胰岛素耐药性,炎症,纤维化) 的新兴疗法的分析.
- 根据印度药物可用性,糖尿病状况和纤维化严重程度开发治疗算法.
主要成果:
- 一些药物表现有前途,包括resmetirom,GLP- 1RAs (半氨酸),PPAR激活剂 (皮奥格利塔,沙罗格利塔),SGLT2抑制剂和维生素E.
- 新兴的疗法,如提泽帕提德和FGF类型,可能会对未来的治疗产生重大影响.
- 在考虑成本效益的前提下, 拟为印度的非脊髓炎 MASLD 管理提供一个实用算法.
结论:
- 药物治疗对于管理逐渐发展的MASLD来说越来越重要,针对特定的致病机制.
- 对印度多元化人口来说, 量身定制的治疗策略,平衡有效性,可负担性和可行性是非常重要的.
- 这一审查为医生提供了在常规临床实践中优化MASLD护理的工具.
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