在全身性红疹狼中由阿扎西奥普林引起的严重脱发
Vijay Kr Rao1, Thanushree N2, Manasa Rs3
1Consultant, Department of Rheumatology, Divisha Arthritis and Medical Center, Bengaluru, Karnataka, India, Corresponding Author, Orcid: https://orcid.org/0009-0005-0926-4912.
The Journal of the Association of Physicians of India
|August 21, 2025
概括
在全身性狼 (SLE) 患者中,阿扎西奥普林 (AZA) 可能会导致严重的骨髓抑制和脱发. 在AZA治疗期间,及时识别和治疗不良反应至关重要.
科学领域:
- 关节病学
- 免疫学
- 皮肤病学
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,表现不同.
- 阿扎西奥普林 (AZA) 是一种用于轻度至中度SLE的常见免疫抑制剂.
- 严重的脱发是AZA治疗的不常见但可能的副作用.
研究的目的:
- 在全身性狼 (SLE) 患者中报告与阿扎西奥普林 (AZA) 相关的严重白血病和脱发症.
- 强调在SLE治疗中认识到AZA引起的不良影响的重要性.
主要方法:
- 一名45岁的女性SLE患者,此前接受了mycophenolate mofetil和氧化治疗,并转为AZA治疗.
- 在AZA开始和剂量升级后,患者出现严重的白血病和脱发.
- 通过血液学咨询诊断出AZA诱导的骨髓抑制和脱发症.
主要成果:
- 在AZA开始治疗后6周,患者出现严重的白血病和显著的脱发.
- 患者被切断了AZA,并重新转换为mycophenolate mofetil.
- 白细胞数量在几周内恢复正常, 但头发的再生需要大约3个月.
结论:
- 骨髓抑制和白血病是AZA在SLE患者中显著的不良影响.
- 严重的脱发也可能是AZA毒性的表现.
- 早期诊断和干预对于治疗AZA相关SLE并发症至关重要.
相关概念视频
Skin Diseases and Disorders
4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
Drugs for Treatment of Ulcerative Colitis in IBD
236
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
236
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
267
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
267
Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
Autoimmune Disorders
671
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
671
Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K


