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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Updated: Sep 10, 2025

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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高分辨率的T2磁力共振成像预测了阿尔茨海默病连续性的认知衰退

Mehrdad Mozafar1, Sahba Shahbazi2,3, Mohammad Amir Amirian4

  • 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Applied neuropsychology. Adult
|August 21, 2025
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概括

中间叶缩,特别是在海马和内皮层等区域,与阿尔茨海默病 (AD) 阶段的认知衰退有关. 这些大脑体积变化是监测AD进展的关键成像标志物.

关键词:
阿尔茨海默病认知能力脑内皮层海马体磁共振成像技术中间叶缩轻度认知障碍神经成像生物标志物

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科学领域:

  • 神经成像
  • 神经学
  • 阿尔茨海默病的研究

背景情况:

  • 中间叶 (MTL) 亚区域缩是阿尔茨海默病 (AD) 的早期指标.
  • 了解MTL体积与认知功能之间的关系对于诊断和跟踪AD进展至关重要.

研究的目的:

  • 调查MTL亚区域体积与AD连续性个体的认知表现之间的关联.
  • 确定与阿尔茨海默病不同阶段认知缺陷相关的特定MTL子区域.

主要方法:

  • 对阿尔茨海默病神经成像计划 (ADNI) 队列276名参与者的高分辨率T2加权MRI数据的分析.
  • 将参与者分为认知正常 (CN),主观记忆问题 (SMC),早期轻度认知障碍 (EMCI),晚期轻度认知障碍 (LMCI) 和AD组.
  • 根据年龄,教育,APOE ε4状态和内体积 (ICV) 进行统计分析,以检查MTL体积与认知分数之间的相关性 (ADAS-13,MMSE,MoCA,Trail Making Test B,记忆回忆).

主要成果:

  • 与其他组相比,在AD参与者中观察到MTL子区域 (角,牙状,脑内皮层,Brodmann区域35) 的显著缩.
  • 特定的MTL区域与认知缺陷相关:CA,DG,BA35和PHC与ADAS-13;CA和SUB与LMCI中的MMSE;ERC与CN和AD中的MoCA;BA36,CS和PHC与LMCI中的Trail Making Test B.
  • 在AD中记忆力较差与CA和DG缩有关,而早期的MCI显示了CA,DG,BA35,SUB和CS语言学习缺陷与缩之间的相关性.

结论:

  • 特定的MTL亚区域的缩与阿尔茨海默病连续性的认知障碍有显著的关联.
  • 这些MTL亚区域的体积变化可以作为早期发现和监测AD认知衰退的有价值的成像生物标志物.
  • 这些发现凸显了神经影像技术在阿尔茨海默病研究中追踪疾病进展和制定治疗策略的潜力.