TOPSS:儿童中风幸存者的跨直流刺激的耐受性
Stuart Fraser1,2, Anna Clearman1,2, Melika Abrahams1,2
1Division of Child and Adolescent Neurology, Department of Pediatrics, McGovern Medical School, University of Texas, Houston, TX, United States.
Frontiers in human neuroscience
|August 21, 2025
概括
超直流刺激 (tDCS) 对于中风相关运动障碍的儿童来说是安全的和可行的. 这种神经调节技术在儿童中风幸存者中改善了手臂功能和灵敏度.
科学领域:
- 神经调节
- 儿童神经学
- 康复医学
背景情况:
- 儿童中风通常会导致长期的运动缺陷.
- 非侵入性神经调节,如跨直流刺激 (tDCS),显示神经发育状况的治疗潜力.
- 关于儿童中风幸存者的安全性和可行性的研究有限.
研究的目的:
- 评估双半球tDCS与职业治疗的安全性,可行性和耐受性.
- 评估儿童和青少年患有童年中风后慢性半衰竭的TDCS.
- 探索潜在的运动功能和灵敏度的改善.
主要方法:
- 一个单臂的开放试验,涉及6至19岁的5名参与者.
- 在职业治疗期间,参与者每天接受5次tDCS (0. 5 - 1.5mA).
- 通过不良事件,生命体征和完成率来监测安全性;使用Fugl-Meyer,COPM和Box and Blocks测试来评估运动功能.
主要成果:
- 所有参与者在没有重大不良事件的情况下完成了研究.
- 在40%的会议中出现轻微的过渡性或刺痛,不限制参与.
- 在3个月内,五分之四的参与者表现出上肢功能显著改善 (Fugl-Meyer);在感知性能和灵敏度方面也出现了改善.
结论:
- 在儿童中风后患有慢性半衰减的儿科患者中,tDCS耐受性良好且可行.
- 这些发现支持tDCS作为这一群体的潜在治疗选择.
- 这项研究为未来儿童中风恢复的随机对照试验提供了初步证据.
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