临床血栓和血液静止中的人工智能:一篇综述
Yi Kiat Isaac Kuan1, Yixin Jamie Kok1, Nigel Sheng Hui Liu2
1Department of Haematology, Tan Tock Seng Hospital, Singapore.
Research and practice in thrombosis and haemostasis
|August 21, 2025
概括
人工智能 (AI) 和机器学习 (ML) 正在彻底改变血液静止和血栓治疗. 这些技术提高了诊断,风险评估和个性化治疗,尽管验证和解释性仍然存在挑战.
科学领域:
- * 医疗信息学
- * 计算生物学
- * 血液学
背景情况:
- 人工智能 (AI) 和机器学习 (ML) 越来越多地应用于静血和血栓形成.
- 应用范围包括诊断,风险评估,实验室测试,患者教育,个性化医疗和药物开发.
研究的目的:
- * 审查AI和ML在血液静止和血栓治疗中的临床效用和局限性.
- 探索AI在这个领域的六个关键领域的应用.
主要方法:
- * 在PubMed,Embase和Scopus数据库中进行全面的文献搜索,截至2025年2月.
- *包括同行评审的英语研究,辅以手册和参考选.
- * 分析了84项研究,重点是风险评估,诊断,个性化医疗,药物开发和患者参与.
主要成果:
- *人工智能在使用成像和EHR数据诊断血栓事件时具有很高的准确性,但存在一些敏感性差距.
- *人工智能改善了实验室错误检测,并在血栓塞栓风险预测中超越传统得分.
- *人工智能可以实现个性化抗凝血,基因严重性预测,增强患者教育和新药发现,但在验证,解释性和偏见方面存在局限性.
结论:
- * 人工智能对诊断,风险预测以及对血栓和血静的个性化治疗具有显著的前景.
- *成功的临床整合需要在医疗保健工作流程中提供透明,有效和公平的人工智能系统.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
893
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
893
Venous Thrombosis III: Interprofessional Care
22
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.3K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
Clot Retraction and Fibrinolysis
6.8K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.8K
Extrinsic and Intrinsic Pathways of Hemostasis
9.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
9.2K
Introduction to Hemostasis
8.9K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.9K


