低ALT水平和COVID-19感染后的心脏衰竭的新诊断
在PubMed上查看摘要
概括
此摘要是机器生成的。在COVID-19感染之前,低氨酸转胺酶 (ALT) 水平与患上充血性心力衰竭 (CHF) 的风险较高有关. 建议这些患者在COVID后立即进行心血管评估.
科学领域
- 心脏病学
- 传染性疾病
- 肝病学
背景情况
- COVID-19 感染可能导致严重并发症,包括充血性心力衰竭 (CHF).
- 确定COVID后的感染前风险因素对于改善患者的结果至关重要.
- 氨酸转胺酶 (ALT) 是一种主要存在于肝脏中的酶,其水平可以表明肝脏的健康状况和潜在的全身炎症.
研究的目的
- 调查基线低氨酸酶 (ALT) 水平与COVID-19感染后新诊断的充血性心力衰竭 (CHF) 之间的联系.
- 确定感染前的ALT水平是否可以作为SARS-CoV-2感染后心脏病发作的预测标志物.
主要方法
- 使用来自Meuchedet健康基金数据库的数据进行了回顾性队列研究.
- 包括检测出SARS-CoV-2阳性的成年患者 (≥18岁) 和感染前测定的ALT水平.
- 排除标准包括先前的CHF或肝硬化诊断,或在SARS-CoV-2感染后30天内死亡;主要终点是新的CHF诊断.
主要成果
- 该研究包括131,953名COVID-19的成年患者,205名 (0.16%) 被诊断为新发性心脏不全.
- 与正常ALT组 (0. 14%) 相比,低ALT组的CHF发生率显著增加 (p < 0. 001).
- 这种关联在50岁及以上的患者中更为明显,多变量逻辑回归证实病前ALT水平较低是COVID后CHF的显著预测因素 (OR=1. 95).
结论
- 在COVID-19感染之前,低基线ALT水平显著与感染后充血性心力衰竭的风险增加有关.
- 在感染COVID-19之前,ALT水平较低的个体需要对任何感染后的病情进行仔细的心血管评估.
- 感染前的ALT水平可能是从COVID-19中康复的患者中分层性心脏病风险的有价值生物标志物.
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