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相关概念视频

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Carbohydrate Metabolism01:36

Carbohydrate Metabolism

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  3. 研究领域
  5. 生物医学和临床科学
  7. 瘤学和致癌症
  9. 预测和预后标志物
  11. 在2型糖尿病中识别和机理性洞察的无素蛋白酶系统和亡相关的生物标志物
  1. 首页
  3. 研究领域
  5. 生物医学和临床科学
  7. 瘤学和致癌症
  9. 预测和预后标志物
  11. 在2型糖尿病中识别和机理性洞察的无素蛋白酶系统和亡相关的生物标志物

相关实验视频

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

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在2型糖尿病中识别和机理性洞察的无素蛋白酶系统和亡相关的生物标志物

Xiao-Jing Yuan1, Zi-Chen Zhang1, Jie Li2

  • 1Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China.

World journal of diabetes
|August 21, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

这项研究确定了四个关键基因 (ABCC8,RBP4,RASGRF1和SLC34A2) 作为2型糖尿病 (T2DM) 相关的生物标志物. 这些发现为T2DM诊断和治疗策略提供了新的途径.

关键词:
生物标志物细胞间生物通信热症监管网络

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Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Published on: May 2, 2025

279

科学领域:

  • 生物化学和分子生物学
  • 遗传学和基因组学
  • 内分泌学

背景情况:

  • 热和无处不在是涉及到糖尿病 (DM) 发病的关键过程.
  • 了解这些细胞机制之间的相互作用对于推进糖尿病研究至关重要.

研究的目的:

  • 在2型糖尿病 (T2DM) 中识别与全方位蛋白酶系统 (UPS) 和热相关的基因.
  • 阐明这些基因在T2DM发病过程中的潜在机制.
  • 发现T2DM诊断和治疗的潜在生物标志物.

主要方法:

  • 使用公共数据集 (GSE76894,GSE41762,GSE86469) 进行差异基因表达分析.
  • 已识别出差异表达的泛素蛋白酶系统基因 (UPSG) 和与热相关的基因 (PRG).
  • 使用斯皮尔曼相关性,t测试,ROC分析,GSEA,ssGSEA和网络构建来识别和验证生物标志物及其相关途径和细胞类型. 使用qPCR和西白斑验证的结果.

主要成果:

  • 在T2DM中确定了四种与ubiquitin- pyroptosis相关的生物标志物:ABCC8,RBP4,RASGRF1和SLC34A2.
  • 这些生物标志物在与DM相关的途径中得到丰富,包括氧化酸化和MAPK信号传递.
  • 观察到免疫细胞丰富的显著差异,并建立了一个涉及miRNAs和lncRNAs的调节网络. 确定了药物相关性,并描述了阿尔法和β细胞等关键细胞类型.
2 型糖尿病
乌比基蛋白酶系统

结论:

  • 通过生物信息学方法成功识别了T2DM的四种与ubiquitin-pyroptosis相关的新生物标志物 (ABCC8,RBP4,RASGRF1,SLC34A2).
  • 这些生物标志物为开发T2DM新诊断和治疗策略提供了宝贵的见解.