Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Liquid crystal biosensing platform based on whispering gallery mode laser for Aβ42 detection.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Co-exposure to microcystin-LR and polystyrene nanoplastics aggravates neuroinflammation by promoting AhR/NF-κB axis-mediated gut microbiota dysfunction.

Environment international·2026
Same author

Piezo2 mechanically regulate scleral fibroblast differentiation by activating relA/RhoA pathway.

Experimental eye research·2026
Same author

Accelerated discovery of thermophilic biocatalysts for marine polysaccharide bioprocessing via ETopt.

International journal of biological macromolecules·2026
Same author

Self-driven recycling of spent Li-ion battery materials with electricity generation.

Nature communications·2026
Same author

Enabling Durable and High-Energy Aqueous Proton Batteries by Engineering a Robust Polymer-Metal Complex Interphase on Mn<sub>2</sub>O<sub>3</sub> Cathode.

Small (Weinheim an der Bergstrasse, Germany)·2026

相关实验视频

Updated: Sep 10, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.0K

患有梅尼尔病的患者血清中的NLRP6炎症和炎症细胞因子IL-1b和IL-18水平之间的相关性

Mengxiao Li1, Ying Zhou1, Zhibiao Liu1

  • 1The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Department of Otolaryngology-Head and Neck Surgery, Huaian, China.

Journal of medical biochemistry
|August 21, 2025
PubMed
概括

其他

科学领域:

  • 耳鼻喉科
  • 免疫学
  • 分子生物学

背景情况:

  • 梅尼尔病的发病率正在上升,
  • 对于改善患者治疗策略至关重要的是了解MD的致病性.

研究的目的:

  • 在MD患者中研究血清中介白素-1b (IL-1b) 和介白素-18 (IL-18) 和NLRP6炎症酶激活之间的关系.
  • 评估这些标志物与MD严重程度的相关性以及它们作为诊断生物标志物的潜力.

主要方法:

  • 实时定量PCR和ELISA用于测量75名MD患者和75名健康对照者的NLRP6mRNA,IL-1b和IL-18水平.
  • 在患者群体 (单侧与双侧MD) 和疾病阶段之间进行了比较分析.
  • 接收器操作特征 (ROC) 曲线分析评估了诊断潜力.

主要成果:

  • 与对照组相比,MD患者的NLRP6,IL- 1b和IL- 18周围血液水平显著升高 (p<0. 001).
  • 在NLRP6,IL-1b和IL-18水平之间发现了正相关性.
  • 晚期MD (III+IV) 与早期MD (I+II) 相比,这些生物标志物的水平较高 (p<0.001).
  • 单边和双边MD病例之间没有显著差异.
关键词:
一个IL-18其他类型梅尼耶尔病NLRP6炎症酶诊断情况

更多相关视频

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.5K
An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
08:40

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

Published on: March 14, 2016

19.3K

相关实验视频

Last Updated: Sep 10, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.0K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.5K
An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
08:40

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

Published on: March 14, 2016

19.3K

结论:

  • 在Meniere病患者的外周血液中,NLRP6,IL-1b和IL-18的表达高.
  • 这些生物标志物可能是梅尼尔病的早期诊断指标.