通过两种不同的方法计算的测量不确定性结果和乙醇测试的总分析误差
Mehmet Akif Bozdayi1, İsmet Gamze Bozdayı2, Gökhan Çakırca1
1Mehmet Akif Inan Education and Research Hospital, Department of Medical Biochemistry, Sanliurfa, Türkiye.
Journal of medical biochemistry
|August 21, 2025
概括
测量不确定性 (MU) 和总分析误差 (TAE) 对于可靠的乙醇测试至关重要. 这项研究计算了MU和TAE,发现值在允许的误差范围内,确保准确的法律值解释.
科学领域:
- 分析化学
- 法医科学
- 实验室医学
背景情况:
- 由于法律影响,乙醇测试中的分析性能指标至关重要.
- 测量不确定性 (MU) 和总分析误差 (TAE) 是评估测量质量的关键指标.
- 可靠的乙醇测试结果对于准确的解释和合规性至关重要.
研究的目的:
- 为了计算乙醇测试的MU和TAE值.
- 从不同的角度评估乙醇测试结果的可靠性.
- 通过两种不同的计算方法,评估MU值对法定门的影响.
主要方法:
- 根据Nordtest和ISO/TS 20914指南计算了MU值.
- 使用公式确定TAE:TAE%=1. 65×CV%+Bias%.
- 使用了2022年7月至2024年6月的外部和内部质量数据.
主要成果:
- 扩大的MU值为13. 95% (Nordtest) 和10. 94% (低水平) / 9. 59% (高水平) (ISO/ TS 20914).
- 计算的TAE值为12. 59 (低),11. 47 (高) 和12. 57 (整体).
- 所有的 MU 和 TAE 值都保持在 ±20% 的 CLIA 2024 允许的总误差范围内.
结论:
- 实验室应与MU值一起报告乙醇测试结果,特别是在法定值附近.
- 建议科学委员会对MU计算方法进行标准化.
- 为了提高一致性和可靠性,建议确定MU的目标限值.
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